Description
Antitargets and Drug Safety (Methods & Principles in Medicinal Chemistry Book 66) 1st Edition
Antitargets and Drug Safety (Methods & Principles in Medicinal Chemistry, Book 66) – 1st Edition is an advanced and authoritative resource that addresses one of the most critical challenges in modern drug development: drug safety and off-target effects. This book is specifically designed for medicinal chemists, pharmaceutical scientists, toxicologists, pharmacologists, and drug discovery researchers who aim to develop safer and more effective therapeutic agents.
This first edition provides a deep scientific insight into the concept of antitargets—biological targets whose unintended interaction with drugs can lead to adverse effects, toxicity, or clinical failure. The book explains why understanding antitargets is essential in early drug discovery and how their identification can significantly reduce late-stage drug attrition. By combining theoretical principles with real-world examples, the text bridges the gap between molecular design and patient safety.
The book systematically explores the mechanisms of off-target interactions, including receptor cross-reactivity, enzyme inhibition, ion channel modulation, and transporter interference. It highlights how these interactions contribute to cardiotoxicity, hepatotoxicity, neurotoxicity, and other safety concerns. Special attention is given to well-known antitargets such as hERG channels, cytochrome P450 enzymes, and nuclear receptors, which are major causes of drug withdrawal.
A key strength of Antitargets and Drug Safety is its strong focus on modern screening strategies and predictive tools. The book discusses in vitro, in vivo, and in silico approaches used to detect safety liabilities early in the drug design process. Topics such as structure–activity relationships (SAR), safety pharmacology, computational modeling, and risk assessment are explained in a clear and practical manner.
As part of the respected Methods & Principles in Medicinal Chemistry series, this volume maintains a high academic standard while remaining relevant to industrial applications. It is particularly valuable for professionals involved in lead optimization, regulatory submission, and translational research, as well as postgraduate students seeking an in-depth understanding of drug safety science.
Now available at BooksHub.pk, this title is an excellent option for readers in Pakistan who want to buy original medicinal chemistry and pharmaceutical sciences textbooks online. BooksHub.pk ensures authentic editions, competitive pricing, and reliable nationwide delivery.
If your goal is to design safer drugs, minimize clinical risk, and understand the hidden causes of drug failure, Antitargets and Drug Safety – 1st Edition is an indispensable reference that belongs in every serious pharmaceutical research library.
Key Features
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In-depth coverage of antitargets and off-target drug interactions
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Strong focus on drug safety and toxicity prevention
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Detailed discussion of hERG, CYP450, and other critical antitargets
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Covers in vitro, in vivo, and in silico safety screening methods
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Integrates medicinal chemistry with pharmacology and toxicology
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Part of the renowned Methods & Principles in Medicinal Chemistry series
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Ideal for researchers, industry professionals, and postgraduate students
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Original edition available online at BooksHub.pk
