Structures and Functions of Retroviral RNAs: The Multiple Facets of the Retroviral Genome
Unlock the secrets of retroviral life cycles with Structures and Functions of Retroviral RNAs: The Multiple Facets of the Retroviral Genome, authored by Philippe Fossé and published by Wiley‑ISTE in October 2022. Now available at Books Hub PK, Pakistan’s trusted academic book supplier, this concise yet powerful volume (176 pp) explores the critical roles played by RNA structure in viral replication, packaging, and pathogenesis — offering invaluable insights particularly relevant for HIV‑1 research and antiviral drug discovery.
Retroviral genomes rely on highly structured RNA elements that guide processes from reverse transcription and splicing to nuclear export and virus assembly. This book delves into these structure–function relationships, revealing how specific folds and motifs control interactions with viral proteins and host factors, influencing genomic dimerization, packaging signal selection (Psi/Ψ), and regulatory mechanisms such as RRE–Rev nuclear export import (Mimicking cellular mRNA machinery).
🔍 Key Features
-
Compact yet comprehensive review of retroviral RNA secondary and tertiary structures that support essential viral functions.
-
Detailed coverage of RNA folding motifs such as stem-loops (e.g., DIS, TAR, Psi packaging signals) and their functional impact on replication.
-
Exploration of RNA–protein and RNA–RNA interactions, including host non-coding RNA packaging and Gag/RNA binding events that modulate infectivity.
-
Highlights emerging therapeutic targets within RNA domains to counter antiviral resistance and support rational drug design.
-
Authored by a leading virology researcher, with emphasis on translational applications in HIV‑1.
